ABSTRACT
Background: The detection of anti-transglutaminase IgA (tTG) and anti-endomysial (EMA) is used for screening of celiac disease (CD) with a sensitivity and specificity of 90 and 99% respectively. There is an association between CD and connective tissue diseases (CTD). Aim: To report the frequency of IgA tTG and EMA in patients with a definite diagnosis of CTD and inflammatory arthropathies (IA). Material and Methods: One hundred forty nine patients, aged 19 to 86 years (133 females) with CTD and IA were studied. tTG were determined by ELISA and EMA by indirect immunofluorescence. Results: Eight participants had at least one positive antibody (5.4%, confidence intervals (CI) = 1.8-9), six had both (4.0% CI = 0.9-7.2) and two had only tTG positive. An intestinal biopsy was performed in four of these participants, finding a marked villous atrophy in three and partial atrophy in one. Conclusions: Five percent of this group of patients with CTD or IA had positive antibodies for CD.
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Antibodies, Anti-Idiotypic/blood , Arthritis/complications , Celiac Disease/diagnosis , Connective Tissue Diseases/immunology , Transglutaminases/immunology , Celiac Disease/complications , Cross-Sectional Studies , Enzyme-Linked Immunosorbent Assay , Fluorescent Antibody Technique, Indirect , Immunoglobulin A/blood , Sensitivity and SpecificityABSTRACT
La Artritis Reumatoide (AR) es una enfermedad inflametoria crónica que compromete predominantemente manos. El objetivo de este trabajo fue determinar la prevalencia de daño radiológico en la mano dominante (MD) de pacientes con AR. Material y métodos: se realizó un estudio transversal, se incluyeron pacientes con AR (ACR 87) de la consulta ambulatoria (noviembre de 2011 a julio de 2012). Se determinó la MD y se realizó lectura radiológica por un lector ciego validado, mediante Sharp van der Heijde modificado. Estadística: se realizó estadística descriptiva básica, y comparaciones mediante Chi2, test de Fisher o test de T para muestras relacionadas según correspondiera. Se consideró p<0,50 como significativa. Resultados: se incluyeron 52 pacientes, 43 mujeres (82,7%), la mediana de edad de 47 años (RIC: 41-56), de evolución de la AR de 10 años (RIC: 3-14). En 50 pacientes (96,2%), la mano derecha fue MD. No se encontraron diferencias estadísticamente significativas en el puntaje total de SvdH modificado, ni de pinzamiento, ni de erosiones. Los varones tuvieron el doble de puntaje medio erosivo, pero no significativo. Conclusión: no se puede demostrar asociación entre la MD y el daño radiológico. Debería estudiarse el subgrupo masculino en estudios de mayor poder estadístico
Rheumatoid Arthritis (RA) is an inflammatory disease that affects thehand joints. The aim of this study was to assess the prevalence of domi-nant hand affection in RA patients. Methods:A cross sectional study was designed that included RA pa-tients (ACR 87 criteria), that concurred to rheumatologic clinic, fromNovember 2011 to July 2012. Descriptive data was taken, and a radio-logic scoring by Sharp van der Heijde score was assessed comparingboth hands. Statistics:The variables were compared by Chi2, Fisher orT-student tests and a p <0.05 value was considered significant.Results: Fifty-two patients were included, 43 female (82.7%), 47 yearsof median age (IQR: 41-56), and 10 years of median disease evolution.In 50 patients (96.2%), the right hand was dominant. There were no dif-ferences between both hands in the total mSvdH score, nor the erosionnor the space narrowing score. Male patients were more prone to havehigher erosive scores, but the number was small (six).Conclusion: No association was seen between radiological damageand dominant hand. Male patients should be included in future studiesto clarify this issue in this sub-group of RA patients.